عوامل مرتبط با افزایش حجم لثه ناشی از سیکلوسپورین در بیماران با پیوند کلّیه
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Abstract:
Background and Aim: Cyclosporine-A (CsA) is commonly prescribed for kidney transplant patients to suppress their immune systems, which can lead to gingival enlargement (GE) . The present study aimed at determining the prevalence of associated factors with CsA-induced gingival enlargement in kidney transplant patients in Rasht during 2012. Materials and Methods: In this cross sectional research, information about kidney transplant patients was recorded in respective questionnaires after their examinations. Then, gingival enlargement and gingival index (GI) were divided into 4 degrees at 4 points and plaque index (PI) was recorded according to Oleary index. Finally, the obtained results were analyzed by means of SPSS Software (V:16), using Chi-square and T-Test. Results: Seventy-five renal transplant patients (31 women and 44 men) with the mean age 43.18 years (age range 18-73years) participated in this study. Gingival enlargement was diagnosed in 50% of the patients that had used cyclosporine. The average dosage of the drug was 179.6 mg. The increased prevalence of gingival enlargement was observed in the maxilla rather than in the mandible and more in the anterior than in the posterior parts of the jaws. Gingival enlargement was significantly correlated with GI and PI (P=0.01 and P=0.03, respectively). Conclusion: PI and GI were higher in patients with gingival enlargement than patients without gingival enlargement. Thus, it is suggested that periodontal proper hygiene be done to prevent gingival enlargement.
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بررسی تأثیر آزیترومایسین در درمان افزایش حجم لثه ناشی از مصرف سیکلوسپورین در بیماران پیوند کلیه
Statement of Problem: Gingival overgrowth is a side effect commonly induced by Cyclosporin treatment. The effects of Azithromycin, a macrolidic antibiotic, has been focused on gingival enlargement treatment induced by cyclosporine in numerous articles. Purpose: The goal of the present study was to survey the effects of systemic Azithromycin in the treatment of gingival overgrowth induced by cyc...
full textبررسی تأثیر آزیترومایسین در درمان افزایش حجم لثه ناشی از مصرف سیکلوسپورین در بیماران پیوند کلیه
بیان مسأله: افزایش حجم لثه (goi) یکی از عوارض جانبی و شایع درمان دارویی سیکلوسپورین می باشد. آزیترومایسین آنتی بیوتیک ماکرولیدی است که تأثیر آن در کاهش افزایش حجم لثه ناشی از مصرف سیکلوسپورین در مقالات متعدد مورد بحث قرار گرفته است.
full textشیوع افزایش حجم لثه و ریسک فاکتورهای آن در بیماران پیوند کلیه دریافت کننده داروهای ایمونوساپرسیو
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Background: Diabetes mellitus increases the risk of central nervous system (CNS) disorders such as stroke, seizures, dementia, and cognitive impairment. Berberine, a natural isoquinolne alkaloid, is reported to exhibit beneficial effect in various neurodegenerative and neuropsychiatric disorders. Moreover astrocytes are proving critical for normal CNS function, and alterations in their activity...
full textاثر بربرین در تنظیم آستروسیتهای Gfap+ ناحیه هیپوکمپ موشهای صحرایی دیابتی شده با استرپتوزوتوسین
Background: Diabetes mellitus increases the risk of central nervous system (CNS) disorders such as stroke, seizures, dementia, and cognitive impairment. Berberine, a natural isoquinolne alkaloid, is reported to exhibit beneficial effect in various neurodegenerative and neuropsychiatric disorders. Moreover astrocytes are proving critical for normal CNS function, and alterations in their activity...
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Journal title
volume 21 issue 4
pages 462- 468
publication date 2015-01
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